Higher Cefazolin Concentrations with Intraosseous Regional Prophylaxis in TKA
نویسندگان
چکیده
منابع مشابه
Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA
BACKGROUND In human TKA studies, intraosseous regional administration (IORA) of prophylactic antibiotics achieves local tissue antibiotic concentrations 10 times greater than systemic administration. However, it is unclear if such high concentrations provide more effective prophylaxis. QUESTIONS/PURPOSES We asked: (1) What prophylaxis dosage and route (intravenous [IV] versus IORA of prophyla...
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BACKGROUND To characterize whether medical comorbidities, depression and anxiety predict patient-reported functional improvement after total knee arthroplasty (TKA). METHODS We analyzed the prospectively collected data from the Mayo Clinic Total Joint Registry for patients who underwent primary or revision TKA between 1993-2005. Using multivariable-adjusted logistic regression analyses, we ex...
متن کاملCefazolin versus cefazolin plus metronidazole for antibiotic prophylaxis at cesarean section.
BACKGROUND Although prophylactic antibiotic medications have been shown to reduce the incidence of postoperative infectious morbidity after cesarean delivery, the most effective regimens have not been established. The purpose of this investigation was to compare the efficacy and costs of prophylaxis with cefazolin alone with cefazolin plus metronidazole. METHODS Women undergoing cesarean deli...
متن کاملEfficacy of Pre Incision Intravenous Single Dose of Cefazolin Versus Multiple Doses of Cefazolin for Antibiotic Prophylaxis for Caesarean Section
Aim : To study the efficacy of pre-incision intravenous single dose of cefazolin versus multiple doses of cefazolin for antibiotic prophylaxis for caesarean section. Materials and methods: This was an interventional, open label, two armed, randomized study conducted in the Department of Obstetrics and Gynaecology at PGIMER, Chandigarh from July 2013 to October 2014. Two hundred women were enrol...
متن کاملIn vitro studies with cefazolin.
Susceptibilities of 259 isolates of pathogenic bacteria to cefazolin were measured by broth and agar dilution procedures. Beta-hemolytic streptococci were inhibited by 0.25 mug/ml, whereas Staphylococcus aureus and alphahemolytic streptococci were inhibited by 2.0 mug/ml. Enterococci were resistant to less than 32 mug/ml. Wide variation was seen with gram-negative species. Most isolates of Kleb...
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ژورنال
عنوان ژورنال: Clinical Orthopaedics & Related Research
سال: 2013
ISSN: 0009-921X
DOI: 10.1007/s11999-012-2469-2